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- Title
Detection of hepatitis B virus DNA sequences in bone marrow of children with leukemia.
- Authors
Pontisso, Patrizia; Locasciulli, Anna; Schiavon, Emma; Cattoretti, Giorgio; Schirò, Raffaella; Stenico, Duilio; Alberti, Alfredo; Pontisso, P; Locasciulli, A; Schiavon, E; Cattoretti, G; Schirò, R; Stenico, D; Alberti, A
- Abstract
To investigate the possibility that hemopoietic cells may become infected with hepatitis B virus (HBV), viral DNA was studied by molecular hybridization in bone marrow aspirates of 51 children with leukemia. HBV-DNA was found in the bone marrow of eight children (15%) and Southern blot analysis revealed the presence of free, monomeric viral sequences. Only one of the eight children with HBV-DNA in bone marrow cells was HBsAg-positive in serum, whereas two additional patients were transiently HBsAg-positive in serum during follow-up, but were negative at the time HBV-DNA was found in bone marrow. Four other cases developed antibodies to HBV. Cases of myeloid leukemia were more frequently positive for HBV-DNA in bone marrow (55%), compared with cases of lymphoid leukemia (7%). These results indicate that hemopoietic cells are susceptible to infection with hepatitis B virus and stimulate new interest into the relation of HBV infection to the development of some forms of leukemia, as four of eight cases of myeloid leukemia were HBV-DNA positive in bone marrow aspirates at diagnosis, prior to receiving any transfusion therapy.
- Publication
Cancer (0008543X), 1987, Vol 59, Issue 2, p292
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19870115)59:2<292::AID-CNCR2820590220>3.0.CO;2-T