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- Title
Adult T-cell leukemia in two siblings. Acute crisis of smoldering disease in one patient.
- Authors
Taguchi, Hirokuni; Niiya, Kenji; Kubonishi, Ichiro; Yano, Shoki; Yoshimoto, Shizuo; Fujishita, Masatoshi; Kitagawa, Takao; Mitani, Masaaki; Miyoshi, Isao; Taguchi, H; Niiya, K; Kubonishi, I; Yano, S; Yoshimoto, S; Fujishita, M; Kitagawa, T; Mitani, M; Miyoshi, I
- Abstract
Two cases of human T-cell leukemia virus (HTLV)-positive adult T-cell leukemia (ATL) in brother and sister are presented. Six of 15 members of this family were seropositive for antibodies for ATL-associated antigens (ATLA). The sister of the ATL patient developed overt ATL after 5 years and 8 months of smoldering ATL. Immunologic examinations during the smoldering phase were normal except for negative skin tests for purified protein derivative. Factors leading to the induction of ATL among HTLV carriers remain to be studied.
- Publication
Cancer (0008543X), 1985, Vol 56, Issue 12, p2870
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19851215)56:12<2870::AID-CNCR2820561226>3.0.CO;2-H