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- Title
Phenotypic and ultrastructural characterization of a medullary thymocyte acute lymphoblastic leukemia with cellular procoagulant activity.
- Authors
Chorba, Terence L.; Orenstein, Jan Marc; Ney, Alan B.; Schwartz, Bradford S.; Alabaster, Oliver; Kessler, Craig M.; Cohen, Philip; Schulof, Richard S.; Chorba, T L; Orenstein, J M; Ney, A B; Schwartz, B S; Alabaster, O; Kessler, C M; Cohen, P; Schulof, R S
- Abstract
The phenotypic and ultrastructural characterization of the blast cells from a T-cell acute lymphoblastic leukemia (T-ALL) that was associated with disseminated intravascular coagulation (DIC) is described. The bone marrow blasts were considered to represent neoplastic medullary thymocytes and were acid phosphatase (+), terminal deoxynucleotidyl transferase (-), acid alpha-naphthyl acetate esterase (-), E-rosette (+) at 4 degrees C and 37 degrees C, Fc- and C3-receptor (-), and cALLA-, Ia-, 9.6+, OKT3+, OKT4+, OKT6+/-, OKT8+, OKT10+. On transmission electron microscopic study, the predominant cell was 6 micron in diameter and possessed an irregular nucleus, moderate-sized nucleolus, marginated heterochromatin, abundant Golgi elements and granules, and prominent intermediate filaments. The cells were analyzed with normal and factor-deficient human plasmas and contained significant amounts of tissue factor-like procoagulant activity. This is the first report of a well-characterized medullary thymocyte T-ALL in which DIC was an accompanying feature, and the first demonstration of tissue factor-like procoagulant activity in acute lymphoblastic leukemia. In view of thrombohemorrhagic phenomena observed in association with other medullary thymocyte leukemias, these findings suggest that tissue factor-like procoagulant activity may be a characteristic of medullary thymocyte-derived lymphoid leukemias.
- Publication
Cancer (0008543X), 1985, Vol 55, Issue 3, p675
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19850201)55:3<675::AID-CNCR2820550334>3.0.CO;2-N