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- Title
Clear cell carcinoma of the ovary with colony-stimulating-factor production. Occurrence of marked granulocytosis in a patient and nude mice.
- Authors
Takeda, Akihiro; Suzumori, Kenji; Sugimoto, Yoshie; Yagami, Yoshiaki; Miyazawa, Takahiko; Yamada, Chieko; Matsuyama, Mutsushi; Takeda, A; Suzumori, K; Sugimoto, Y; Yagami, Y; Miyazawa, T; Yamada, C; Matsuyama, M
- Abstract
A case of clear cell carcinoma of the ovary with colony-stimulating-factor (CSF) production is presented. Granulocytosis (54,200/mm3) of unknown cause was observed in a patient at the terminal stage of the clinical course. This tumor was successfully heterotransplanted into athymic nude mice, and transplantable tumor line was designated as OCL-1. OCL-1 tumor reproduced granulocytosis up to 640,000/mm3 in nude mice, and CSF production was demonstrated by colony-forming assay using tumor extract and mouse bone marrow cells in vitro. This is the first report that describes the case of CSF-producing clear cell carcinoma of the ovary and its heterotransplantation in nude mice.
- Publication
Cancer (0008543X), 1984, Vol 54, Issue 6, p1019
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19840915)54:6<1019::AID-CNCR2820540615>3.0.CO;2-R