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- Title
Doxazosin selectively potentiates contraction to serotonin via 5-HT<sub>2A</sub> receptors in longitudinal muscle strips of the rabbit gastric body.
- Authors
Zhao, Yan; Cao, Xue-Bin; Ren, Lei-Ming
- Abstract
The aims of this study were to examine the effects of doxazosin on contractile responses to 5-hydroxytryptamine (5-HT), carbachol, and histamine, and to compare them with those of prazosin, alfuzosin, and terazosin, and then characterize a pharmacological profile of the 5-HT-induced contractile response using preparations of isolated longitudinal muscle strips from the rabbit gastric body. The results from these preparations showed that the contraction response to 5-HT, but not to carbachol or histamine, was found to be dose-dependently potentiated by doxazosin and its enantiomers. The specific potentiation effect on 5-HT was not observed in the preparations that were treated with prazosin, terazosin, or alfuzosin. The contractile response to 5-HT and its potentiation by doxazosin were not affected by treatment with phenoxybenzamine. However, 5-HT-induced contraction was competitively antagonized by nefazodone (with p A2 value of 8.64 ± 0.17), and was almost completely inhibited by treatment with indomethacin. In conclusion, doxazosin, but not prazosin, alfuzosin, or terazosin, selectively potentiates 5-HT-induced contraction in the rabbit gastric body strips via an α1-adrenoceptor-independent mechanism, without chiral recognition of its enantiomers. Additionally, the contraction to 5-HT was found to be mediated via 5-HT2A receptors, and was similar to PGs synthesis in the preparations.
- Subjects
DOXAZOSIN; SEROTONIN; CARBACHOL; HISTAMINE; PRAZOSIN; LABORATORY rabbits; PHENOXYBENZAMINE (Drug)
- Publication
Canadian Journal of Physiology & Pharmacology, 2014, Vol 92, Issue 3, p197
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2013-0067