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- Title
The senescent antigen hypothesis of RBC evanescence: 50 years of correlation without causation.
- Authors
Zimring, James C.; Spitalnik, Steven L.; Hudson, Krystalyn E.
- Abstract
In vivo, IgG was shown to increase on the surface of older RBCs in humans, mice,3 and dogs,4 and the resulting eluted IgG can opsonize damaged older RBCs. However, a critical examination of the evidence does not support this level of confidence in the SA hypothesis and seriously undermines the conclusion that anti-SA are required for RBC clearance, or that they even have anything at all to do with clearing older RBCs. A recent letter to I Transfusion i by Badior et al. has reported that IgG eluted from red blood cells (RBCs) of 20 blood donors binds to native degraded Band3,1 supporting earlier elegant studies by the same group using X-ray crystallography that defined a discontinuous Band3 eptiope2 as the target of antibodies to the senescent antigen (SA).
- Subjects
CELLULAR aging; ERYTHROCYTES
- Publication
Transfusion, 2022, Vol 62, Issue 11, p2414
- ISSN
0041-1132
- Publication type
letter
- DOI
10.1111/trf.17095