We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK Sloane Project.
- Authors
Shaaban, Abeer M.; Hilton, Bridget; Clements, Karen; Provenzano, Elena; Cheung, Shan; Wallis, Matthew G.; Sawyer, Elinor; Thomas, Jeremy S.; Hanby, Andrew M.; Pinder, Sarah E.; Thompson, Alastair M.; Sloane Project Steering Committee
- Abstract
<bold>Background: </bold>The Sloane audit compares screen-detected ductal carcinoma in situ (DCIS) pathology with subsequent management and outcomes.<bold>Methods: </bold>This was a national, prospective cohort study of DCIS diagnosed during 2003-2012.<bold>Results: </bold>Among 11,337 patients, 7204 (64%) had high-grade DCIS. Over time, the proportion of high-grade disease increased (from 60 to 65%), low-grade DCIS decreased (from 10 to 6%) and mean size increased (from 21.4 to 24.1 mm). Mastectomy was more common for high-grade (36%) than for low-grade DCIS (15%). Few (6%) patients treated with breast-conserving surgery (BCS) had a surgical margin <1 mm. Of the 9191 women diagnosed in England (median follow-up 9.4 years), 7% developed DCIS or invasive malignancy in the ipsilateral and 5% in the contralateral breast. The commonest ipsilateral event was invasive carcinoma (n = 413), median time 62 months, followed by DCIS (n = 225), at median 37 months. Radiotherapy (RT) was most protective against recurrence for high-grade DCIS (3.2% for high-grade DCIS with RT compared to 6.9% without, compared with 2.3 and 3.0%, respectively, for low/intermediate-grade DCIS). Ipsilateral DCIS events lessened after 5 years, while the risk of ipsilateral invasive cancer remained consistent to beyond 10 years.<bold>Conclusion: </bold>DCIS pathology informs patient management and highlights the need for prolonged follow-up of screen-detected DCIS.
- Subjects
BREAST cancer surgery; ADENOCARCINOMA; RESEARCH; RESEARCH methodology; PROGNOSIS; MEDICAL cooperation; EVALUATION research; DUCTAL carcinoma; BREAST cancer; COMPARATIVE studies; RESEARCH funding; MASTECTOMY; BREAST tumors; LONGITUDINAL method
- Publication
British Journal of Cancer, 2021, Vol 124, Issue 5, p1009
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/s41416-020-01152-5