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- Title
The duck genome and transcriptome provide insight into an avian influenza virus reservoir species.
- Authors
Huang, Yinhua; Li, Yingrui; Burt, David W; Chen, Hualan; Zhang, Yong; Qian, Wubin; Kim, Heebal; Gan, Shangquan; Zhao, Yiqiang; Li, Jianwen; Yi, Kang; Feng, Huapeng; Zhu, Pengyang; Li, Bo; Liu, Qiuyue; Fairley, Suan; Magor, Katharine E; Du, Zhenlin; Hu, Xiaoxiang; Goodman, Laurie
- Abstract
The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.
- Subjects
BIRDS; GENETICS; TRANSCRIPTION factors; AVIAN influenza A virus; MALLARD; BUTYROPHILIN; IMMUNE response; DEFENSINS; HOST-virus relationships
- Publication
Nature Genetics, 2013, Vol 45, Issue 7, p776
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.2657