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- Title
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population.
- Authors
Shiraishi, Kouya; Kunitoh, Hideo; Daigo, Yataro; Takahashi, Atsushi; Goto, Koichi; Sakamoto, Hiromi; Ohnami, Sumiko; Shimada, Yoko; Ashikawa, Kyota; Saito, Akira; Watanabe, Shun-ichi; Tsuta, Koji; Kamatani, Naoyuki; Yoshida, Teruhiko; Nakamura, Yusuke; Yokota, Jun; Kubo, Michiaki; Kohno, Takashi
- Abstract
Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, Pcombined = 2.8 × 10?40, odds ratio (OR) = 1.41) and 3q28 (rs10937405, Pcombined = 6.9 × 10?17, OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, Pcombined = 7.4 × 10?11, OR = 1.20) and 6p21.3 (rs3817963, Pcombined = 2.7 × 10?10, OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.
- Subjects
LUNG cancer &; genetics; ADENOCARCINOMA; DISEASE susceptibility; LOCUS (Genetics); GENOMES; JAPANESE people; DISEASES
- Publication
Nature Genetics, 2012, Vol 44, Issue 8, p900
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.2353