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- Title
Targeted Disruption of the Murine Gene Coding for the Third Complement Component (C3).
- Authors
Pekna; Hietala; Rosklint; Betsholtz; Pekny
- Abstract
Complement is a system of more than 30 proteins found both in plasma and on cell membranes. The complement system has several important functions in the immune response including initiation of inflammation, neutralization and elimination of pathogens, regulation of antibody responses, clearance of immune complexes and disruption of cell membranes. Under certain conditions complement may, however, act as a mediator of deleterious inflammatory reactions and complement activation has been implicated in the pathogenesis of autoimmune disorders, atherosclerosis, neurodegenerative diseases, bioincompatibility reactions and decompression sickness. Using gene targeting, we have generated mice deficient for the third complement component (C3). These mice represent an animal model in which complement activation by any pathway is prevented at an early stage. The C3-deficient mice should be valuable for the study of the roles of the complement system in vivo in a variety of physiological and pathological situations.
- Subjects
GENES; COMPLEMENT (Immunology); IMMUNE system
- Publication
Scandinavian Journal of Immunology, 1998, Vol 47, Issue 1
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.1998.00274.x