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- Title
Natural Killer and T-Cell Potentiation by Monoclonal IgG against Natural Killer Cell FcR(IgG) or the T3 Complex.
- Authors
Jondal, M.; Kullman, C.; Alter, M.-B.; Ljunggren, K.
- Abstract
Treatment of human natural killer (NK) cells with monoclonal antibodies of the IgG isotype against NK cell-FcR(IgG) increased lysis of most haematopoietic target cell lines with high or intermediate background NK susceptibility. Treatment of normal non-adherent lymphocytes with an IgG anti-T3 monoclonal antibody also increased lysis against the same target cells. Potentiating anti-FcR antibodies rapidly modulated FcR activity and the capacity of the cells to act as antibody-dependent killers, although such antibodies were demonstrable for a long time at the cell surface, Anti-FcR treatment did not influence concanavalin A (Con A)-dependent killing, in contrast to anti-T3 treatment, which suppressed lectin-dependent lysis but did not influence antibody-dependent killing. The data is compatible with a ‘pro-receptor’ theory for FcR in NK killing, stating that such receptors may function in the same way as the T3 complex interacts with specific T cell receptors.
- Subjects
IMMUNOGLOBULINS; CELLS; IMMUNOGLOBULIN G; MONOCLONAL antibodies; LYMPHOCYTES; KILLER cells; LEUCOCYTES
- Publication
Scandinavian Journal of Immunology, 1986, Vol 23, Issue 6, p639
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1986.tb01999.x