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- Title
In Vitro Immune Response of SLE Lymphocytes.
- Authors
Takeuchi, T.; Abe, T.; Kiyotaki, M.; Toguchi, T.; Koide, J.; Morimoto, C.; Homma, M.
- Abstract
Peripheral blood lymphocytes from 26 patients with systemic lupus erythematosus (SLE) and six normal individuals were tested for IgG synthesis in the presence or absence of PWM, Lymphocytes from patients with active SLE synthesized increased amounts of IgG in the absence of PWM and reduced amounts of IgG in the presence of PWM. Scrum from patients with active SLE had an enhancing effect on the in vitro IgG synthesis of normal lymphocytes. The IgG or F(ab')2 a fractions of SLE scrum retained the enhancing effect on in vitro IgG synthesis, and the enhancing activity was absorbed by human spleen cell. As little as 4 h of incubation with SLE serum was needed for the enhancing activity of normal lymphocytes. Treatment of B lymphocytes appeared to be of main importance for in increase in the in vitro IgG synthesis of SLE- serum-treated lymphocytes, These results suggest that anti-B-lymphocyte antibodies from patients with active SLE are responsible in part for the hyperactive response of SLE B lymphocytes.
- Subjects
IMMUNE response; LYMPHOCYTES; SYSTEMIC lupus erythematosus; IMMUNOGLOBULIN G; SERUM; COLLAGEN diseases
- Publication
Scandinavian Journal of Immunology, 1982, Vol 16, Issue 5, p369
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1982.tb00737.x