We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Studies on Human Epidermal Langerhans Cells IV. HLA-D Restriction of Langerhans Cell-Dependent Antigen Activation of T Lymphocytes.
- Authors
Braathen, L. R.; Thorsby, E.
- Abstract
Epidermal cell suspensions were produced containing 3-6% HLA-DR-positive Langerhans cells. By using mixtures of epidermal cells and allogeneic T lymphocytes from donors sensitized to purified protein derivative of tuberculin (PPD) and herpes simplex virus (HSV), we could show that a proliferative in vitro response to these antigens, similar in strength to that seen in autologous combinations of macrophages or epidermal cells and T cells, could be obtained provided the epidermal cells shared both HLA-D/DR determinants with the T-cell donor. No antigen-specific response was obtained in fully HLA-D/DR-disparate combinations. These results, together with previously reported data using other antigen-presenting cells, further emphasize that one minimal requirement for antigen-specific activation of T cells is co-recognition of products of the self HLA-D region.
- Subjects
CELL suspensions; LANGERHANS cells; T cells; TUBERCULIN; MACROPHAGES; ANTIGENS
- Publication
Scandinavian Journal of Immunology, 1982, Vol 15, Issue 1, p55
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1982.tb00621.x