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- Title
Effect of surgical intervention on serum insulin-like growth factor 1 in patients with obstructive sleep apnoea.
- Authors
Jaiswal, A S; Valappil, B V; Gupta, Y; Sikka, K; Thakar, A; Verma, H
- Abstract
Objective: To evaluate the effect of surgical intervention on serum insulin-like growth factor 1 levels in patients with obstructive sleep apnoea. Methods: A prospective study was conducted in a tertiary care hospital of adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy failed or was refused. All patients underwent polysomnography and serum insulin-like growth factor 1 evaluation pre-operatively and at three months post-operatively. The site of surgery was determined using Müller's manoeuvre and ApneaGraph AG 200. Results: Fifteen patients were included with a mean age of 38 years: 11 males and 4 females. The mean pre-operative Apnoea–Hypopnoea Index using polysomnography was 53.7 events per hour, and the mean post-operative Apnoea–Hypopnoea Index at three months was 15.3 events per hour (p = 0.0001). The mean pre-operative serum insulin-like growth factor 1 was 160.2 μg/l, while the mean post-operative value was 236.98 μg/l (p = 0.005). Conclusion: In adult patients with obstructive sleep apnoea for whom continuous positive airway pressure therapy fails, site-specific surgical intervention to treat the obstruction leads to an increase in serum insulin-like growth factor 1 levels.
- Subjects
SOMATOMEDIN; CONTINUOUS positive airway pressure; TERTIARY care; POLYSOMNOGRAPHY; TREATMENT effectiveness; SLEEP apnea syndromes; LONGITUDINAL method
- Publication
Journal of Laryngology & Otology, 2023, Vol 137, Issue 11, p1222
- ISSN
0022-2151
- Publication type
Article
- DOI
10.1017/S0022215123000348