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- Title
Potential mechanisms between periodontitis and Alzheimer's disease: a scoping review.
- Authors
Lamphere, Abrielle K.; Nieto, Valerie K.; Kiser, Jessica R.; Haddlesey, Chris B.
- Abstract
Background: Research has suggested 2 potential mechanisms by which the periodontal inflammatory response may communicate to distant organs: 1) direct translocation of periodontal bacteria from the oral cavity to another organ system; and 2) inflammation as a result of metastatic periodontal inflammation. The purpose of this scoping review is to explore these mechanisms as potential mediators between periodontitis and Alzheimer's disease. Methods: A reiterative literature search of peer-reviewed articles was performed in the PubMed and Scopus databases using keywords or combinations such as Alzheimer's disease AND periodontitis OR periodontal disease AND inflammation. Results: A total of 777 articles were identified. After eliminating duplicates and reviewing titles and abstracts, 84 articles were selected for full-text review. Following full-text review, 19 articles met the eligibility criteria for the study. Discussion: The review of the literature highlights how periodontitis may contribute to neuroinflammation by the introduction of periodontal bacteria and/ or proinflammatory cytokines locally produced at the periodontium. Conclusion: Inflammation is an important mechanism in the onset and progression of both periodontitis and Alzheimer's disease. Nevertheless, further studies are necessary to better understand the multifactorial pathogenesis of Alzheimer's disease.
- Subjects
DISEASE progression; ONLINE information services; ALZHEIMER'S disease; PERIODONTITIS; SYSTEMATIC reviews; INFLAMMATION; LITERATURE reviews; MEDLINE
- Publication
Canadian Journal of Dental Hygiene, 2023, Vol 57, Issue 1, p52
- ISSN
1712-171X
- Publication type
Article