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- Title
The association of ROS1 mutation with cancer immunity and its impact on the efficacy of pan-cancer immunotherapy.
- Authors
Li, Yingying; Zhao, Hong; Huang, Jinyuan; Yan, Huimeng; Zhao, Bin
- Abstract
This letter, published in the Journal of Translational Medicine, discusses the association between ROS1 mutation and cancer immunity, as well as its impact on the efficacy of pan-cancer immunotherapy. The authors conducted a comprehensive analysis using bioinformatics and clinical data, finding that ROS1 mutation was associated with longer overall survival and increased response to immune checkpoint inhibitors. They also explored the immune characteristics of ROS1-mutant tumors, including higher mutation loads, increased expression of immune-related molecules, and enhanced immune cell infiltration. Overall, the study suggests that ROS1 mutation may serve as a favorable biomarker for outcomes in pan-cancer immunotherapy.
- Subjects
GENETIC mutation; IMMUNOTHERAPY
- Publication
Journal of Translational Medicine, 2024, Vol 22, Issue 1, p1
- ISSN
1479-5876
- Publication type
Article
- DOI
10.1186/s12967-024-05166-y