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- Title
Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges.
- Authors
Foti, Riccardo; Storti, Gabriele; Palmesano, Marco; Scioli, Maria Giovanna; Fiorelli, Elena; Terriaca, Sonia; Cervelli, Giulio; Kim, Bong Sung; Orlandi, Augusto; Cervelli, Valerio
- Abstract
Adipose tissue-derived stem cells (ADSCs) represent a subset of the mesenchymal stem cells in every adipose compartment throughout the body. ADSCs can differentiate into various cell types, including chondrocytes, osteocytes, myocytes, and adipocytes. Moreover, they exhibit a notable potential to differentiate in vitro into cells from other germinal lineages, including endothelial cells and neurons. ADSCs have a wide range of clinical applications, from breast surgery to chronic wounds. Furthermore, they are a promising cell population for future tissue-engineering uses. Accumulating evidence indicates a decreased proliferation and differentiation potential of ADSCs with an increasing age, increasing body mass index, diabetes mellitus, metabolic syndrome, or exposure to radiotherapy. Therefore, the recent literature thoroughly investigates this cell population's senescence mechanisms and how they can hinder its possible therapeutic applications. This review will discuss the biological mechanisms and the physio-pathological causes behind ADSC senescence and how they can impact cellular functionality. Moreover, we will examine the possible strategies to invert these processes, re-establishing the full regenerative potential of this progenitor population.
- Subjects
CELL populations; STEM cells; MESENCHYMAL stem cells; CELLULAR aging; BODY mass index; BREAST
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 15, p8390
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25158390