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- Title
Vasorelaxant and Hypotensive Effects of Galla chinensis in Rats.
- Authors
Shin, Sujin; Park, Junkyu; Choi, Ho-Young; Bu, Youngmin; Lee, Kyungjin
- Abstract
Previous studies have revealed the medicinal and therapeutic effects of Galla chinensis. However, no studies have focused on the antihypertensive effects of G. chinensis. Therefore, we aimed to determine the vasorelaxant and hypotensive effects of G. chinensis 50% ethanolic extract (GCE). To evaluate the vascular relaxing effect of GCE, experiments were conducted using aortic segments dissected from Sprague Dawley rats. GCE showed a vasorelaxant effect via the nitric oxide/cyclic guanosine 3′,5′-monophosphate pathway, inhibiting Ca2+ channels, and activating K+ channels. The hypotensive effects of GCE were evaluated in spontaneously hypertensive rats (SHRs). The SHRs were randomly divided into a control group and orally administered GCE group (100 or 300 mg/kg). The systolic and diastolic blood pressure decreased significantly by −19.47 ± 4.58% and −31.14 ± 7.66% in the GCE 100 mg/kg group, and −21.64 ± 2.40% and −31.91 ± 5.75% in the GCE 300 mg/kg group at 4 h after administration. Considering its vasorelaxant and hypotensive effects, our results indicate that GCE may be a valuable solution for the control of hypertension. However, further studies on the long-term administration and toxicity of GCE are required.
- Subjects
RATS; DIASTOLIC blood pressure; SPRAGUE Dawley rats; SYSTOLIC blood pressure; TREATMENT effectiveness; CALCIUM antagonists; MUSCLE relaxants; BLOOD pressure
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 14, p7962
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25147962