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- Title
Dietary carotenoids intake and sex differences in relation to chronic kidney disease a cross-sectional assessment in the NHANES study.
- Authors
Shi, Yumeng; Xu, Yanjie; Zhou, Wei
- Abstract
Background and aims: Current evidence on the relationship between dietary carotenoids intake (DCI) and chronic kidney disease (CKD) are limited. Moreover, whether there is an association between DCI and prevalence of CKD and how this association might be impacted by sex is not clear. Methods and results: Overall, 4507 women and 4396 men were included for analysis. The study used data from the National Health and Nutrition Examination Survey (NHANES), a cross-sectional survey carried out in the USA. The exposure factor for this analysis was DCI. The outcome was CKD, defined as eGFR < 60mL/min/1.73 m2. Multivariate logistic regression was used to analyzed the associations of DCI and prevalence of CKD both in men and women. There was a significant inverse association between higher DCI and prevalence of CKD only among females. Per LgDCI unit increment, the multivariable adjusted odd ratio (OR) (95% confidence interval) for prevalence of CKD was 0.72 (0.58, 0.90) in females and 0.95 (0.77, 1.18) in males. When compared with the lowest quartile, the ORs of the highest quartile of DCI for prevalence of CKD were 0.59 (0.40, 0.87) in females and 0.87 (0.60, 1.26) in males. The associations remained similar in the subgroup analyses. Conclusions: The findings suggest that a higher intake of dietary carotenoids is associated with a lower prevalence of CKD in women, but not in men. Highlights: The present study provides evidence that a higher DCI is specifically associated with a reduced prevalence of CKD in women, regardless of other potential confounding factors for CKD. In clinical practice, female patients can be encouraged to eat more foods rich in carotenoids to prevent the occurrence and development of CKD and related cardiovascular diseases, while for men, it is still the main risk factor for the control of CKD.
- Subjects
CHRONIC kidney failure; FOOD consumption; HEALTH &; Nutrition Examination Survey
- Publication
BMC Public Health, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2458
- Publication type
Article
- DOI
10.1186/s12889-024-17771-z