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Title
Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.
Investigates the interaction of sarcomeric protein titin with muscle-specific RING finger-1 (MURF-1). Expression of MURF-1; Disruption of the integrity of the M-line region of titin; Results of the disruption.