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- Title
Conjugated Linoleic Acid-Curcumin Attenuates Cognitive Deficits and Oxidative Stress Parameters in the Ethidium Bromide–Induced Model of Demyelination.
- Authors
Barzegarzadeh, Behnaz; Hatami, Homeira; Dehghan, Gholamreza; Khajehnasiri, Nazli; Khoobi, Mehdi; Sadeghian, Reihaneh
- Abstract
Oxidative stress has been shown to play an important role in the pathogenesis of multiple sclerosis (MS). Curcumin (CUR), an antioxidant compound, can be a potent treatment for neurodegenerative diseases, such as MS. CUR has poor bioavailability; therefore, it is used in nanoforms to increase its bioavailability. In the present study, the effects of CUR and conjugated linoleic acid-CUR (Lino-CUR) on spatial memory and oxidative stress in a putative animal model of MS were investigated. Forty-nine adult male Wistar rats (250 ± 50 g) were randomly divided into seven groups (n = 7): control, sham, ethidium bromide (EB), CUR (20 and 40 μg/kg) + EB, and Lino-CUR (20 and 40 μg/kg) + EB groups. Following MS induction, the groups were treated for 5 consecutive days. Finally, spatial memory and levels of oxidative stress parameters were assessed. Treatment with CUR and Lino-CUR at two doses significantly improved spatial memory and reduced oxidative stress parameters in the experimental models of MS. Furthermore, the effects of high dose (40 μg/kg) of Lino-CUR were more remarkable. These findings suggest that the microinjection of CUR in its synthetic form Lino-CUR significantly ameliorated spatial memory, through the reduction of oxidative stress markers in the brain of studied animals as a rat model of MS.
- Subjects
ETHIDIUM; SPATIAL memory; DEMYELINATION; EFFECT of stress on animals; LABORATORY rats
- Publication
Neurotoxicity Research, 2021, Vol 39, Issue 3, p815
- ISSN
1029-8428
- Publication type
Article
- DOI
10.1007/s12640-020-00310-0