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- Title
Mechanism of Cardioprotection: What Can We Learn from Females?
- Authors
Murphy, Elizabeth; Lagranha, Claudia; Deschamps, Anne; Kohr, Mark; Nguyen, Tiffany; Renee Wong; Junhui Sun; Steenbergen, Charles
- Abstract
This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed.
- Subjects
ESTROGEN; HEART cells; NITRIC oxide; CARDIOVASCULAR diseases; MENOPAUSE; PHYSIOLOGY
- Publication
Pediatric Cardiology, 2011, Vol 32, Issue 3, p354
- ISSN
0172-0643
- Publication type
Article
- DOI
10.1007/s00246-010-9877-4