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- Title
Evidence of a common cell origin in a case of pancreatic mixed intraductal papillary mucinous neoplasm-neuroendocrine tumor.
- Authors
Schiavo Lena, Marco; Cangi, Maria Giulia; Pecciarini, Lorenza; Francaviglia, Ilaria; Grassini, Greta; Maire, Renaud; Partelli, Stefano; Falconi, Massimo; Perren, Aurel; Doglioni, Claudio
- Abstract
Recently, the term mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) has been proposed as an umbrella definition covering different possible combinations of mixed neuroendocrine-exocrine neoplasms. Among these, the adenoma plus neuroendocrine tumor (NET) combination is among the rarest and not formally recognized by the 2019 WHO Classification. In this setting, the debate between either collision tumors or true mixed neoplasms is still unsolved. In this report, a pancreatic intraductal papillary mucinous neoplasm (IPMN) plus a NET is described, and the molecular investigations showed the presence in both populations of the same KRAS, GNAS, and CDKN2A mutations and the amplification of the CCND1 gene. These data prove clonality and support a common origin of both components, therefore confirming the true mixed nature. For this reason, mixed neuroendocrine-exocrine neoplasms, in which the exocrine component is represented by a glandular precursor lesion (adenoma/IPMN) only, should be included into the MiNEN family.
- Subjects
CARCINOSARCOMAS; NEUROENDOCRINE tumors; ADENOMA; TUMORS
- Publication
Virchows Archiv: European Journal of Pathology, 2021, Vol 478, Issue 6, p1215
- ISSN
0945-6317
- Publication type
journal article
- DOI
10.1007/s00428-020-02942-1