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- Title
Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma.
- Authors
Jun-ichiro Ikeda; Eiichi Morii; Yasuhiko Tomita; Binglin Zhang; Toshiteru Tokunaga; Masayoshi Inoue; Masato Minami; Meinoshin Okumura; Katsuyuki Aozasa
- Abstract
Abstract??Mediastinal lymphangiomatosis in a 70-year-old woman was diagnosed on a medical checkup. The tumor was resistant to sclerotherapy with OK432 or bleomycin. The patient continued on a downhill course and died approximately 3?years after the initial diagnosis. Autopsy revealed a large tumor mass occupying the anterior mediastinum and firmly adhered to the pericardium and the pleura. The tumor consisted of two intermingled lesions: dilated vessels lined with D2-40-positive lymphatic endothelium and CD5-positive atypical cell nests with focal keratinization. The former was diagnosed as lymphangiomatosis and the latter as thymic squamous cell carcinoma. Vascular endothelial growth factor (VEGF)-C, a growth factor for lymphatic endothelial cells, was expressed by the carcinoma, and VEGF-C receptor was expressed by the endothelium of lymphangiomatosis. These findings suggested that VEGF-C derived from the thymic carcinoma induced the lymphangiomatosis lesion in a paracrine manner.
- Subjects
LYMPHANGIOMYOMATOSIS; CANCER patients; LUNG diseases; SQUAMOUS cell carcinoma
- Publication
Virchows Archiv: European Journal of Pathology, 2007, Vol 450, Issue 2, p211
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-006-0333-z