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- Title
Development of Experimental Cystoisospora canis Infection Models in Beagle Puppies and Efficacy Evaluation of 5 % Ponazuril (Toltrazuril sulfone) Oral Suspension.
- Authors
C. Reinemeyer; D. Lindsay; S. Mitchell; H.-C. Mundt; S. Charles; R. Arther; T. Settje
- Abstract
Abstract In a pilot study, three pairs of Beagle puppies were inoculated with 2.5, 3.75 or 5 x 104 sporulated oocysts of Cystoisospora canis. All exhibited patent infections within ten days post-inoculation. In an efficacy study, 33 puppies were given 5 x 104 oocysts of C. canis and randomly allocated to receive 20, 30, 40, or 50 mg/kg ponazuril on day 0, or 30 mg/kg ponazuril or placebo on days 0 and 7. Clinical health observations and oocyst excretion were monitored daily post treatment. All dosages decreased oocyst counts > 97 % (P 4 oocysts on days –10, –8 and –6. Puppies were allocated to receive 30 or 50 mg/kg ponazuril on day 0, or 30 mg/kg ponazuril or placebo on days 0 and 7. All dosages decreased oocyst counts (P
- Subjects
PUPPIES; INFECTION; ANTIPROTOZOAL agents; PLACEBOS
- Publication
Parasitology Research, 2007, Vol 101, Issue s0, p129
- ISSN
0932-0113
- Publication type
Article
- DOI
10.1007/s00436-007-0620-x