We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Heparin/heparan sulphate interactions with complement—a possible target for reduction of renal function loss?
- Authors
Zaferani, Azadeh; Talsma, Ditmer; Richter, Mareike K.S.; Daha, Mohamed R.; Navis, Gerjan J.; Seelen, Marc A.; van den Born, Jacob
- Abstract
Current management of end-stage renal failure is based on renal replacement therapy by dialysis or transplantation. Increased occurrence of renal failure in both native and transplanted kidneys indicates a need for novel therapies to stop or limit the progression of the disease. Acute kidney injury and proteinuria are major risk factors in the development of renal failure. In this regard, innate immunity plays an important role in the pathogenesis of renal diseases in both native and transplanted kidneys. The complement system is a major humoral part of innate defense. Next to the well-known complement activators, quite a number of the complement factors react with proteoglycans (PGs) both on cellular membranes and in the extracellular compartment. Therefore, these interactions might serve as targets for intervention. In this review, the current knowledge of interactions between PGs and complement is reviewed, and additionally the options for interference in the progression of renal disease are discussed.
- Subjects
HEPARIN; HEPARAN sulfate; COMPLEMENT (Immunology); KIDNEY function tests; CHRONIC kidney failure; HEMODIALYSIS; KIDNEY transplantation
- Publication
Nephrology Dialysis Transplantation, 2014, Vol 29, Issue 3, p515
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gft243