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- Title
Anti-asthmatic potential of a D-galactose-binding lectin from Synadenium carinatum latex.
- Authors
Alexandre P Rogerio; Cristina R Cardoso; Caroline Fontanari; Maria A Souza; Sandra R Afonso-Cardoso; Érika VG Silva; Natalia S Koyama; Fernanda L Basei; Edson G Soares; João B Calixto; Sean R Stowell; Marcelo Dias-Baruffi; Lúcia H Faccioli
- Abstract
Extracts from the plant Synadenium carinatum latex are widely and indiscriminately used in popular medicine to treat a great number of inflammatory disorders and although the mechanisms underlying these effects remain undefined, the lectin isolated from S. carinatum latex (ScLL) is thought to be in part responsible for these anti-inflammatory effects. In order to elucidate possible immunoregulatory activities of ScLL, we investigated the effects of ScLL administration in models of acute and chronic inflammation. Oral administration of ScLL significantly inhibited neutrophil and eosinophil extravasation in models of acute and chronic inflammation and reduced eosinophil and mononuclear blood counts during chronic inflammation. ScLL administration reduced IL(interleukin)-4 and IL-5 levels but increased interferon-γ and IL-10 in an asthma inflammatory model, which suggested that it might induce a TH2 to TH1 shift in the adaptive immune response. ScLL also inhibited IκBα degradation, a negative regulator of proinflammatory NF-κB. Taken together, these results provide the first description of a single factor isolated from S. carinatum latex extract with immunoregulatory functions and suggest that ScLL may be useful in the treatment of allergic inflammatory disorders.
- Subjects
GALACTOSE; LECTINS; LATEX; INFLAMMATION; NEUTROPHILS; ASTHMA
- Publication
Glycobiology, 2007, Vol 17, Issue 8, p795
- ISSN
0959-6658
- Publication type
Article
- DOI
10.1093/glycob/cwm053