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- Title
TNFα in patients with congestive heart failure.
- Authors
Ceconi, Claudio; Boraso, Antonella; Mele, Donato; Guardigli, Raffaele; Ferrari, Roberto
- Abstract
It is now generally accepted that chronically extensive stimulation of the cytokine system—and of TNFα in particular—is detrimental to the heart and to peripheral tissue and that such stimulation may contribute to the pathogenesis of congestive heart failure of various causes. During the past decade, basic and clinical research has provided growing evidence for the role of systemic and local inflammatory responses that, however, have so far failed to translate into new treatments for patients. The present paper represents an attempt to critically review the general concepts that lie behind the dichotomy existing between an impressive bulk of biologic research showing the role of TNFα as a pathogen in congestive heart failure and the difficulties in translating this evidence into patients’ treatment.
- Subjects
CYTOKINES; TUMOR necrosis factors; HEART failure; HEART disease research; HEART diseases; TISSUES; CARDIAC patients
- Publication
Basic Research in Cardiology, 2004, Vol 99, Issue 1, p12
- ISSN
0300-8428
- Publication type
Article
- DOI
10.1007/s00395-003-0443-6