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- Title
Incidence and clinical outcomes of atypical pituitary adenomas.
- Authors
Moussa, Ahmad A.; Mahmoud, Mohamed E.; Yousef, Hosam A.
- Abstract
Background: Atypical pituitary adenoma has a high rate of recurrence and most of them need further treatment after surgery. This is why early detection is very important. Methods: In this study we examined the incidence and outcome of large atypical pituitary adenoma in our patient cohort. The study was a retrospective review of fifty consecutive patients at Assiut university hospital. They all had a large adenoma with supracellar and parasellar extension. They were considered unsuitable for transphenoidal approach. They all had craniotomy. This study was carried out during a thirty eight month period. Pathology reports were reviewed. All patients had MIB-1 immunohistochemical data. Patients with lesions showing excessive MIB-1immunoreactivity and mitotic features had p53 immunohistochemical data. Results: Ten (20%) of our patients had lesions that met all the criteria for atypical adenoma. Conclusion: Atypical pituitary adenoma tend to be aggressive and invasive macroadenomas. Following surgery, further treatment such as radiotherapy should be considered.
- Subjects
PITUITARY cancer; CANCER relapse; CRANIOTOMY; IMMUNOHISTOCHEMISTRY; CANCER radiotherapy
- Publication
Egyptian Journal of Neurosurgery, 2018, Vol 33, Issue 1, pN.PAG
- ISSN
2520-8225
- Publication type
Article
- DOI
10.1186/s41984-018-0011-x