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- Title
Prognostic Value of Serum BNP in Patients with NSTEMI and Its Correlation with Extent of Coronary Artery Disease.
- Authors
Ismail, Hossam; Gad, Marwa Mohamed; Elawady, Mohamed; El Tahlawi, Mohammad
- Abstract
Background: BNP biomarker is found to have a positive correlation to coronary artery disease (CAD). So it may have diagnostic and prognostic valu e. This study aims to predict the prognostic value of serum BNP level as a biomarker and the severity and complexity of CAD in nnon-ST-elevationmyocardial infarction (NSTEMI) with normal left ventricular (LV) systolic function (preserved ejection fraction) as regards both SYNTAX score and GRACE score. We enrolled patients who presented with NSTEMI and normal LV systolic function (LV EF =50Grace'srace score was calculated. All patients underwent BNP analysis, echocardiography, and coronary angiography within 24 to 72 hours of admission. SYNTAX score was calculated. Results: Sixty-four patients with NSTEMI with a mean GRACE score 140.41 ±28.5 and a mean SYNTAX score of 17.39 ±9.8 were enrolled. BNP level was 135.17 ±37.9ng/dL. According to the level of serum BNP, Patients were divided into 2 groups, the first group with high BNP (>80 ng/dl) and second group with low serum BNP level. The results showed significant differences between both groups regarding the GRACE score (p =0.001) and SYNTAX score (p =0.001). Also, there were significant positive correlations between BNP and age (p =0.001), Grace score (p =0.001), and SYNTAX score (p =0.001). At a cutoff of 141pg/dL, the BNP yielded a sensitivity of 83% and specificity of 75% for the prediction of SYNTAX score of more than 32. Conclusion: Serum BNP level as a biomarker provides independent prognostic value in NSTEMI patients. Patients with high serum BNP levels were more likely to have higher GRACE and SYNTAX scores. Serum BNP level had good diagnostic accuracy in predicting SYNTAX score.
- Subjects
CORONARY artery disease; HEART disease diagnosis; ECHOCARDIOGRAPHY; CORONARY angiography; ST elevation myocardial infarction
- Publication
Zagazig University Medical Journal, 2023, Vol 29, Issue 1, p183
- ISSN
1110-1431
- Publication type
Article
- DOI
10.21608/zumj.2021.61535.2120