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- Title
DR5 Activation of Caspase-8 Induces DC Maturation and Immune Enhancement In Vivo.
- Authors
Chattergoon, Michael A.; Muthumani, Karuppiah; Tamura, Yutaka; Ramanathan, Mathura; Shames, Jason P.; Saulino, Vera; Robinson, Tara M.; Montaner, Luis J.; Weiner, David B.
- Abstract
Non-homeostatic tissue apoptosis in vivo has been shown to induce inflammatory responses and facilitate the cross-presentation of proteins within apoptotic bodies. We hypothesize that in the presence of foreign antigens, the apoptotic-inflammatory process improves immune priming; further, molecules that trigger apoptosis may be adapted for use as immune adjuvants. One very attractive molecule in this context is the tumor necrosis factor receptor (TNFR) family molecule DR5/TRAIL-receptor 2. We show a significant improvement in CD8+ T-cell mediated vaccine immunity with the use of death receptor-5 (DR5) as an immune adjuvant, a property that is correlated with the activation of caspases-8 (casp8) and dependent on its ability to induce apoptosis in vivo.Molecular Therapy (2007); 16 2, 419–426. doi:10.1038/sj.mt.6300373
- Subjects
TISSUES; APOPTOSIS; ANTIGENS; IMMUNOLOGICAL adjuvants; VACCINATION; CELL receptors; GENE therapy
- Publication
Molecular Therapy, 2008, Vol 16, Issue 2, p419
- ISSN
1525-0016
- Publication type
Article
- DOI
10.1038/sj.mt.6300373