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- Title
Use of Winemaking By-Products for the Functionalization of Polylactic Acid for Biomedical Applications.
- Authors
Verano-Naranjo, Lidia; Cejudo-Bastante, Cristina; Casas, Lourdes; Martínez de la Ossa, Enrique; Mantell, Casimiro
- Abstract
The addition of naturally active compounds to implantable polymers is an efficient strategy against inflammation issues that might lead to rejection, while promoting controlled re-endothelialization of the tissues. This work proposes the use of winemaking by-products with high active properties of biomedical interest to obtain bioactive PLA by using supercritical technologies. First, two red grape pomace extracts, obtained by high-pressure extraction with supercritical CO2 and cosolvents (either ethanol or water–ethanol), have been studied. Second, two impregnation methods have been studied with both extracts, traditional supercritical CO2-assisted impregnation (SSI) and a novel pressurized soaking method (PSI). The amount of extract impregnated as well as the bioactivity levels achieved—i.e., antioxidant, antimicrobial, and anti-inflammatory properties— have been determined for each extract and impregnation method at different pressure and temperature conditions. Both extracts obtained had good antioxidant, anti-inflammatory, and antibacterial capacities, especially the hydroethanolic one (0.50 ± 0.03 mg TE/g versus 0.24 ± 0.03 mg TE/g, respectively). Regarding impregnated filaments, impregnation loadings depended especially on the extract and P/T conditions, providing up to 8% (extract mass/polymer mass) of impregnation. The antioxidant capacity increased noteworthily by using the ethanolic extract by PSI, with values near 100 µg TE/g PLA.
- Subjects
POLYLACTIC acid; OXIDANT status; GRAPES
- Publication
Antioxidants, 2023, Vol 12, Issue 7, p1416
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox12071416