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- Title
Lipid Profile, Antioxidant and Antihypertensive Activity, and Computational Molecular Docking of Diatom Fatty Acids as ACE Inhibitors.
- Authors
Pekkoh, Jeeraporn; Phinyo, Kittiya; Thurakit, Theera; Lomakool, Sureeporn; Duangjan, Kritsana; Ruangrit, Khomsan; Pumas, Chayakorn; Jiranusornkul, Supat; Yooin, Wipawadee; Cheirsilp, Benjamas; Pathom-aree, Wasu; Srinuanpan, Sirasit
- Abstract
Diatoms, as single cell eukaryotic microalgae, are rich sources of lipids, which have either beneficial or detrimental effects on the prevention and treatment of many diseases. Gas chromatography-mass spectrometry (GC-MS) identified diatom lipids with high levels of essential fatty acids (EFAs), especially polyunsaturated FAs (PUFAs) containing both omega-3 and omega-6. Nutritional values of FAs indicated possible applications in the pharmaceutical, nutraceutical, and functional food industries. Diatom FAs showed antioxidative potential on harmful radicals by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) scavenging, with high inhibition of the angiotensin-converting enzyme (ACE) that causes cardiovascular disease (CVD) and hypertension. A computational molecular docking simulation confirmed the inhibition mechanisms of FAs on ACE, with comparable levels of binding free energy to chemically synthesized ACE drugs. Findings suggested that diatom lipids showed potential for use as alternative ACE inhibitors or food supplement for CVD prevention.
- Subjects
MOLECULAR docking; ACE inhibitors; OMEGA-6 fatty acids; ANGIOTENSIN I; ANGIOTENSIN converting enzyme; FATTY acids; ESSENTIAL fatty acids; GAS chromatography/Mass spectrometry (GC-MS)
- Publication
Antioxidants, 2022, Vol 11, Issue 2, p186
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox11020186