We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cardiovascular disease: PDE9A inhibition mends broken hearts.
- Authors
Bray, Natasha
- Abstract
The article discusses research on the possible effectivity of phosphodiesteras 9A (PDE9A) inhibition in the treatment of heart failure with preserved ejection fraction (HFPEF). It references the study "Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease" by D. I. Lee and colleagues in the journal "Nature." Also mentioned are the factors that trigger level increase of cGMP protein kinase such as atrial natriuretic peptide (ANP) and nitric oxide (NO).
- Subjects
PHOSPHODIESTERASE inhibitors; HEART failure treatment; HEART diseases; THERAPEUTICS; CARDIOVASCULAR disease treatment; EFFECT of drugs on the heart; ATRIAL natriuretic peptides; NITRIC oxide; CGMP-dependent protein kinase
- Publication
Nature Reviews Drug Discovery, 2015, Vol 14, Issue 5, p310
- ISSN
1474-1776
- Publication type
Article
- DOI
10.1038/nrd4618