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- Title
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells.
- Authors
Liqing Wang; de Zoeten, Edwin F.; Greene, Mark I.; Hancock, Wayne W.; Wang, Liqing
- Abstract
Classical zinc-dependent histone deacetylases (HDACs) catalyse the removal of acetyl groups from histone tails and also from many non-histone proteins, including the transcription factor FOXP3, a key regulator of the development and function of regulatory T cells. Many HDAC inhibitors are in cancer clinical trials, but a subset of HDAC inhibitors has important anti-inflammatory or immunosuppressive effects that might be of therapeutic benefit in immuno-inflammatory disorders or post-transplantation. At least some of these effects result from the ability of HDAC inhibitors to enhance the production and suppressive functions of FOXP3(+) regulatory T cells. Understanding which HDACs contribute to the regulation of the functions of regulatory T cells may further stimulate the development of new class- or subclass-specific HDAC inhibitors with applications beyond oncology.
- Subjects
HISTONE deacetylase; NONHISTONE chromosomal proteins; T cells; CLINICAL trials; AMIDASES; PROTEIN metabolism; DRUG delivery systems; INFLAMMATION; DRUG design; IMMUNOLOGICAL adjuvants; ENZYME inhibitors; TRANSPLANTATION of organs, tissues, etc.; PHARMACODYNAMICS
- Publication
Nature Reviews Drug Discovery, 2009, Vol 8, Issue 12, p969
- ISSN
1474-1776
- Publication type
journal article
- DOI
10.1038/nrd3031