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- Title
Vaginal Microbiota and Proinflammatory Status in Patients with Polycystic Ovary Syndrome: An Exploratory Study.
- Authors
Espinosa, María Elena; Melo, Angélica; Leon, Marion; Bautista-Valarezo, Estefanía; Zambrano, Fabiola; Uribe, Pamela; Bravo, Anita; Taubert, Anja; Hermosilla, Carlos; Iturrieta, Virginia; Sánchez, Raul
- Abstract
Background/Purpose: Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disease most common in patients of childbearing age. This pathology is associated with clinical, metabolic, and reproductive complications. We evaluated the diversity of the vaginal microbiota (VM), the vaginal inflammatory reaction (VIR), the proinflammatory state, and the activation of polymorphonuclear neutrophils (PMN) with the production of neutrophil extracellular traps (NETs). Methods: Thirty-three patients who attended a consultation at the Hospital UTPL-Santa Inés, Loja, Ecuador, from May to August 2023 who were diagnosed with PCOS participated in this study. Blood samples, vaginal discharge, and a survey were obtained. Results: A high number of patients, 23/33 (69.7%), presented altered microbiota in clinical variables associated with PCOS phenotypes A and B, sexual partners (>2), and oligomenorrhoea. A significant statistical association was only observed for sexually transmitted infections at sampling (p = 0.023) and insulin (p = 0.002). All eight cases studied with VIR had PMN/NETotic activity. A high frequency of proinflammatory states was observed in all vaginal microbiota states. Conclusions: These results suggest that the PCOS could trigger a proinflammatory state in the vaginal epithelium independently of the state of the vaginal microbiota. Furthermore, the presence of NETs observed in the cases studied could decrease fertility in these PCOS patients.
- Subjects
POLYCYSTIC ovary syndrome; INFLAMMATION; SEXUALLY transmitted diseases; BACTERIAL vaginitis; CHILDBEARING age; VAGINAL discharge; THYROID cancer
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 8, p2278
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13082278