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- Title
Asthma Phenotypes in the Era of Personalized Medicine.
- Authors
Gonzalez-Uribe, Victor; Romero-Tapia, Sergio J.; Castro-Rodriguez, Jose A.
- Abstract
Asthma is a widespread disease affecting approximately 300-million people globally. This condition leads to significant morbidity, mortality, and economic strain worldwide. Recent clinical and laboratory research advancements have illuminated the immunological factors contributing to asthma. As of now, asthma is understood to be a heterogeneous disease. Personalized medicine involves categorizing asthma by its endotypes, linking observable characteristics to specific immunological mechanisms. Identifying these endotypic mechanisms is paramount in accurately profiling patients and tailoring therapeutic approaches using innovative biological agents targeting distinct immune pathways. This article presents a synopsis of the key immunological mechanisms implicated in the pathogenesis and manifestation of the disease's phenotypic traits and individualized treatments for severe asthma subtypes.
- Subjects
INDIVIDUALIZED medicine; ASTHMA; PHENOTYPES; IMMUNOSPECIFICITY; THERAPEUTICS
- Publication
Journal of Clinical Medicine, 2023, Vol 12, Issue 19, p6207
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm12196207