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- Title
Enfortumab-vedotin use for urothelial carcinoma in two patients on hemodialysis.
- Authors
Khosla, Harshit; Bhatt, Sita; Wang, Ming-Jin; Gignac, Gretchen; Mittal, Kriti; Patel, Jasmine
- Abstract
Enfortumab vedotin (EV) is a novel treatment option for patients with advanced/metastatic urothelial carcinoma who have progressed after chemotherapy and immunotherapy. Two patients at two different New England tertiary cancer care centers were treated with EV while concurrently receiving hemodialysis (HD), where a complete response to EV in both patients was noted. The use of EV in patients requiring HD is extrapolated from the available pharmacokinetic and pharmacodynamic literature on monoclonal antibodies in patients requiring HD. There is a paucity of data for the use of antibody-drug conjugates like EV in patients needing dialysis.
- Subjects
ULTRASONIC imaging of the abdomen; THERAPEUTIC use of antineoplastic agents; THERAPEUTIC use of monoclonal antibodies; COMBINATION drug therapy; BLADDER tumors; LIVER tumors; CYSTOSCOPY; EDEMA; IMMUNOTHERAPY; ANTINEOPLASTIC agents; HEMODIALYSIS; ACUTE kidney failure; POSITRON emission tomography computed tomography; NEPHRECTOMY; CHRONIC kidney failure; MONOCLONAL antibodies; METASTASIS; HYDRONEPHROSIS; TRANSURETHRAL prostatectomy; COMORBIDITY
- Publication
Journal of Oncology Pharmacy Practice, 2024, Vol 30, Issue 5, p941
- ISSN
1078-1552
- Publication type
Article
- DOI
10.1177/10781552241237752