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- Title
富马酸替诺福韦二吡呋酯片联合双环醇在治疗慢性乙型病毒性肝炎方面的研究.
- Authors
程聪; 吴英英; 林山锑; 雷丽萍; 刘有顺
- Abstract
Objective: To study the clinical effect of tenofovir dipivoxil fumarate tablets (TDF) combined with bicyclol in the treatment of chronic viral hepatitis B. Methods: From January 2017 to January 2020, 80 patients with chronic hepatitis B who were admitted to the infectious ward of the Disease Prevention and Control Department of the 73rd Army Hospital of the Chinese People's Liberation Army were selected and randomly divided into two groups. Group 40 cases were treated with TDF, and 40 cases in the study group were treated with TDF combined with bicyclol. The efficacy and adverse reaction rates of the two groups were observed after treatment, and the levels of serum hepatitis B virus DNA (Deoxyribonucleic acid) before and after treatment in the two groups were detected. The level of serum alanine aminotransferase (ALT). Results: After treatment, the total effective rate of the study group was 95.0%, which was significantly higher than the total effective rate of 75.0% in the control group (P<0.05); 32 cases of the study group had serum hepatitis B virus DNA levels <500 cps/mL, accounting for 80.0%, 14 cases in the control group <500 cps/mL, accounting for 35.0%, the comparison was statistically significant (P<0.05); the serum ALT levels of the two groups were significantly reduced, and the study group was lower than the control group (P<0.05) ). The total incidence of adverse reactions in the study group was 2.5%, which was significantly lower than 25.0% in the control group (P<0.05). Conclusion: Tenofovir disoproxil fumarate tablets (TDF) combined with bicyclol has a significant effect in the treatment of chronic hepatitis B. It can significantly reduce the level of serum hepatitis B virus DNA in patients, and is safe and reliable. It is worthy of clinical promotion and application.
- Subjects
PEOPLE'S Liberation Army (China); HEPATITIS B virus; DNA; VIRAL hepatitis; DNA viruses; ALANINE aminotransferase; CHRONIC hepatitis B
- Publication
Progress in Modern Biomedicine, 2021, Vol 21, Issue 3, p502
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2021.03.021