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- Title
Correlations of Serum Chemerin with MMPs and Vascular Endothelial Function in Carotid Atherosclerosis in Patients with Hypertension.
- Authors
JIANG Jian-wen; YANG Ya-me
- Abstract
Objective To investigate the correlations of serum chemerin with MMPs and vascular endothelial function in carotid atherosclerosis in patients with hypertension. Methods One hundred and twenty-four patients with hypertension were divided into high blood pressure without carotid atherosclerosis group (Group A, 63 cases) and hypertension with carotid atherosclerosis group (Group B, 61 cases), while 40 cases of healthy people were selected as a control group (Group C).Chemerin, MMP-3, MMP-9, TIMP-1, ICAM-1 and VCAM-1 were detected. Results Chemerin in group A increased significantly than group C (P< 0.05), while ICAM-1 and VCAM-1 showed no significant differences between the two groups (P > 0.05). Compared with groups A and C, chemerin, ICAM-1 and VCAM-1 have significantly increased in group B (P< 0.05). MMP-9 in group A were significantly higher than that in group C (P< 0.05), but MMP-3 and TIMP-1 showed no significant differences (P > 0.05). MMP-3, MMP-9 and TIMP-1 in Group B showed significant differences in comparison with groups A and C (P< 0.05). Chemerin showed significant positive correlations with ICAM-1, VCAM-1 and MMP-3 (P< 0.05), a significant negative correlation with TIMP-1 ( P < 0.05), and a significant positive correlation with MMP-9 (P<0.01). Conclusion Chemerin is closely related to MMPs and adhesion molecules in hypertension patients, which is an important risk factor for carotid atherosclerosis in patients with hypertension
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 3, p98
- ISSN
2095-610X
- Publication type
Article