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- Title
Dietary supplementation with omega-3 fatty acids and oleate enhances exercise training effects in patients with metabolic syndrome.
- Authors
Ortega, Juan F.; Morales‐Palomo, Felix; Fernandez‐Elias, Valentin; Hamouti, Nassim; Bernardo, Francisco J.; Martin‐Doimeadios, Rosa C.; Nelson, Rachael K.; Horowitz, Jeffrey F.; Mora‐Rodriguez, Ricardo
- Abstract
<bold>Objective: </bold>We studied the effects of exercise training alone or combined with dietary supplementation of omega-3 polyunsaturated fatty acids (Ω-3PUFA) and oleate on metabolic syndrome (MSyn) components and other markers of cardiometabolic health.<bold>Methods: </bold>Thirty-six patients with MSyn underwent 24 weeks of high-intensity interval training. In a double-blind randomized design, half of the group ingested 500 mL/day of semi-skim milk (8 g of fat; placebo milk) whereas the other half ingested 500 mL/day of skim milk enriched with 275 mg of Ω-3PUFA and 7.5 g of oleate (Ω-3 + OLE).<bold>Results: </bold>Ω-3 + OLE treatment elevated 30% plasma Ω-3PUFA but not significantly (P = 0.286). Improvements in VO2peak (12.8%), mean blood pressure (-7.1%), waist circumference (-1.8%), body fat mass (-2.9%), and trunk fat mass (-3.3%) were similar between groups. However, insulin sensitivity (measured by intravenous glucose tolerance test), serum concentration of C-reactive protein, and high-density lipoprotein improved only in the Ω-3 + OLE group by 31.5%, 32.1%, and 10.3%, respectively (all P < 0.05). Fasting serum triacylglycerol, glucose, and plasma fibrinogen concentrations did not improve in either group after 24 weeks of intervention.<bold>Conclusions: </bold>Diet supplementation with Ω-3PUFA and oleate enhanced cardiometabolic benefits of intense aerobic exercise training in patients with MSyn.
- Subjects
EXERCISE; DIETARY supplements; OMEGA-3 fatty acids; OLEATES; METABOLIC syndrome; PATIENTS
- Publication
Obesity (19307381), 2016, Vol 24, Issue 8, p1704
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.21552