Several letters to the editor are presented in response to articles in volume 73, 2005 issues, including "Dexmedetomidine as a sole sedating agent with local anesthesia in a high risk patient for axillofemoral bypass graft," J.M. Rich, and "The Certified Registered Nurse Anesthesist: Occupational responsibilities, perceived stressors, coping strategies, and work relationships," by T.R. Perry.