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- Title
Automated Liquid–Liquid Microextraction of Fluoroquinolones for Their Subsequent Chromatographic Determination.
- Authors
Timofeeva, I. I.; Barbayanov, K. A.; Bulatov, A. V.
- Abstract
An automated method is developed for dispersive liquid–liquid microextraction of fluoroquinolone antibiotics based on the principles of stepwise injection analysis. The method involves the dispersion of the extractant by the gas phase, formed in situ in the extraction chamber of the flow analyzer. A deep eutectic solvent based on a terpenoid and a mixture of hydrophilic and hydrophobic carboxylic acids is studied as an extractant for the isolation and preconcentration of fluoroquinolones, and a possibility of its use is substantiated. Hydrophilic carboxylic acid in the composition of the extractant acts as a proton donor for the formation of a carbon dioxide dispersant in the presence of sodium carbonate dissolved in the aqueous phase. A possibility of combining the developed method with high-performance liquid chromatography with fluorimetric detection is shown on an example of the determination of fluoroquinolones in wastewaters. The limits of detection (3σ) for ofloxacin, fleroxacin, and norfloxacin were 0.3 µg/L.
- Subjects
CHOLINE chloride; HIGH performance liquid chromatography; IN situ processing (Mining); CARBOXYLIC acids; SODIUM carbonate; CARBON dioxide; FLUOROQUINOLONES
- Publication
Journal of Analytical Chemistry, 2023, Vol 78, Issue 2, p207
- ISSN
1061-9348
- Publication type
Article
- DOI
10.1134/S1061934823020132