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- Title
Clinical Utility of Next-Generation Flow-Based Minimal Residual Disease Assessment in Patients with Multiple Myeloma.
- Authors
Hyun-Young Kim; In Young Yoo; Dae Jin Lim; Hee-Jin Kim; Sun-Hee Kim; Sang Eun Yoon; Seok Jin Kim; Duck Cho; Kihyun Kim
- Abstract
Background: Minimal residual disease (MRD) is an important prognostic factor for evaluating a deeper treatment response in patients with multiple myeloma (MM). We evaluated the clinical utility of next-generation flow (NGF)-based MRD assessment in a heterogeneous MM patient population. Methods: Patients with suspected morphological remission after or during MM treatment were prospectively enrolled. In total, 108 bone marrow samples from 90 patients were analyzed using NGF-based MRD assessment according to the EuroFlow protocol, and progression-free survival (PFS) was evaluated according to the International Myeloma Working Group response status, cytogenetic risk, and MRD status. Results: The overall MRD-positive rate was 31.5% (34/108 samples), and MRD-positive patients showed a lower PFS than MRD-negative patients (P =0.005). MRD-positive patients showed inferior PFS than MRD-negative in patients with stringent complete remission (sCR)/complete remission (P=0.014) and high-risk cytogenetic abnormalities (P=0.016). MRD was assessed twice in 18 patients with a median interval of 12 months. Sustained MRD negativity was only observed in patients with sustained sCR, and their PFS was superior to that of patients who were not MRD-negative (P =0.035). Conclusions: Clinical application of NGF-based MRD assessment can provide valuable information for predicting disease progression in patients with MM in remission, including those with high-risk cytogenetic abnormalities.
- Subjects
MULTIPLE myeloma; CANCER remission; PROGRESSION-free survival; BONE marrow; DISEASE progression; CYTOGENETICS
- Publication
Annals of Laboratory Medicine, 2022, Vol 42, Issue 5, p558
- ISSN
2234-3806
- Publication type
Article
- DOI
10.3343/alm.2022.42.5.558