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- Title
Neuron‐inducing therapy using embryonic neural progenitor cells embedding positively charged gold nanoparticles in rats with complete spinal cord injury.
- Authors
Han, Gong H.; Ko, Wan‐Kyu; Kim, Seong J.; Lee, Daye; Jeong, Dabin; Han, Inbo; Sheen, Seung H.; Sohn, Seil
- Abstract
Neuron-inducing therapy using embryonic neural progenitor cells embedding positively charged gold nanoparticles in rats with complete spinal cord injury Traumatic spinal cord injury (SCI) results in neuron loss and axon degeneration at the injury area.1 Embryonic-spinal-cord-derived neural progenitor cells (NPCs) have been highlighted given that NPCs can differentiate into neurons.2 However, under SCI most NPCs undergo differentiation into astrocytes rather than into neurons.3 Glial fibrillary acidic protein (GFAP) barriers from activated astrocytes following SCI disrupt the recovery of damaged neurons/axons in injured areas.4 We aimed to improve injured neurons using NPCs embedding positively charged gold nanoparticles (GNPs) in complete SCI rats. Taken together, among the groups of pGNP-treated NPCs, nGNP-treated NPCs and non-GNP-treated NPCs (w/o GNP), the pGNP-treated NPCs showed greatest differentiation into neurons and lowest into astrocytes. Representative images in the (A and I) injury group, (B and J) neural progenitor cell (NPC) group and (C and K) NPC-positively charged gold nanoparticles (pGNP) group of SCI rats.
- Subjects
SPINAL cord injuries; GOLD nanoparticles; NEURAL stem cells; PROGENITOR cells; GLIAL fibrillary acidic protein; AXONS
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 7, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.981