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- Title
Live or let die: Translational insights and clinical perspectives of gasdermin B‐dependent intestinal epithelial cell fate.
- Authors
Privitera, Giuseppe; Pizarro, Theresa T.
- Abstract
Notably, as opposed to IEC-derived GSDMB-FL function(s), the contribution of non-IEC effector cells (e.g. cytotoxic lymphocytes) is paramount for GSDMB-NT activation and subsequent IEC lysis. Our group recently reported a critical role for the lipid-binding protein and gasdermin B (GSDMB), in intestinal wound healing,1 adding to a growing body of evidence indicating that GSDMB exerts important and multifaceted functions in intestinal epithelial cells (IECs). For example, as pyroptosis is a form of pro-inflammatory cell death, the possibility of GSDMB-mediated pyroptosis promoting intestinal inflammation in IBD certainly needs to be considered; on the other hand, it is plausible that GSDMB-dependent regulation of cell proliferation and adhesion/migration might also play a role in tumour progression.
- Subjects
EPITHELIAL cells; INFLAMMATORY bowel diseases; INTESTINES; CROHN'S disease; FOCAL adhesion kinase; CYTOTOXIC T cells
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 4, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.787