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- Title
Assessment of the skin penetration properties of different carrier vehicles for topically applied cortisol.
- Authors
Ayres, P. J. W.; Hooper, G.
- Abstract
Four commercially available topical preparations of cortisol, Alphaderm, Calmurid MC, Efcortelan and Topisone, had trace quantities of tritiated cortisol added to them. The resultant radiolabelled creams were applied to the dorsum of the pig and the penetration of the steroid was assessed. Alpha-derm was shown to deliver ∼ 16.0 times more cortisol to the skin than Topisone, ∼ 8.0 times more than Efcortelan and ∼ 3.0 times more than Calmurid HC.
- Subjects
HYDROCORTISONE; SKIN diseases; DERMATOLOGY; DRUGS; BIOACTIVE compounds; THERAPEUTICS
- Publication
British Journal of Dermatology, 1978, Vol 99, Issue 3, p307
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1978.tb02002.x