We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hemodynamics and urinary excretion of kidney‐injury biomarkers in pediatric kidney transplantation.
- Authors
Voet, Marieke; van Lier, Dirk; Lemson, Joris; Zarbock, Alex; Malagon, Ignacio; Cornelissen, Elisabeth; Pickkers, Peter
- Abstract
This article discusses the hemodynamics and urinary excretion of kidney injury biomarkers in pediatric kidney transplantation. The study aimed to investigate the relationship between perioperative hemodynamic values and the excretion of acute kidney injury biomarkers in pediatric kidney transplantation with a large donor-acceptor size mismatch. The results suggest that an increased cardiac output (CO) is required to limit postreperfusion donor kidney injury, but excessive therapy to reach a supraphysiological CO, such as high central venous pressure (CVP) and vasopressor infusion rates, may be associated with early donor kidney injury. Further research is needed to determine the clinical consequences of hemodynamic therapy and the most sensitive biomarkers for detecting early donor kidney injury in pediatric kidney transplantation.
- Subjects
HEMODYNAMICS; EXCRETION; KIDNEY transplantation; NEPHRECTOMY; CENTRAL venous pressure; BIOMARKERS; KIDNEY physiology; MYCOBACTERIUM avium paratuberculosis
- Publication
Pediatric Transplantation, 2024, Vol 28, Issue 1, p1
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/petr.14637