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- Title
The Risk of Some Veterinary Antimicrobial Agents on Public Health Associated with Antimicrobial Resistance and their Molecular Basis.
- Authors
Haihong Hao; Sander, Pascal; Iqbal, Zahid; Yulian Wang; Guyue Cheng; Zonghui Yuan
- Abstract
The risk of antimicrobial agents used in food-producing animals on public health associated with antimicrobial resistance continues to be a current topic of discussion as related to animal and human public health. In the present review, resistance monitoring data, and risk assessment results of some important antimicrobial agents were cited to elucidate the possible association of antimicrobial use in food animals and antimicrobial resistance in humans. From the selected examples, it was apparent from reviewing the published scientific literature that the ban on use of some antimicrobial agents (e.g., avoparcin, fluoroquinolone, tetracyclines) did not change drug resistance patterns and did not mitigate the intended goal of minimizing antimicrobial resistance. The use of some antimicrobial agents (e.g., virginiamycin, macrolides, and cephalosporins) in food animals may have an impact on the antimicrobial resistance in humans, but it was largely depended on the pattern of drug usage in different geographical regions. The epidemiological characteristics of resistant bacteria were closely related to molecular mechanisms involved in the development, fitness, and transmission of antimicrobial resistance.
- Subjects
ANTI-infective agents; VETERINARY medicine; PUBLIC health; DRUG resistance in bacteria
- Publication
Frontiers in Microbiology, 2016, Vol 7, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2016.01626