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- Title
Dactinomycin-Induced, Severe Lichenoid Eruption in a Child.
- Authors
Ridola, V.; Mahé, E.; Fawaz, O.; Galmiche, L.; Patte, C.; Grill, J.
- Abstract
There is little information in the medical literature about skin rashes associated with dactinomycin in the absence of radiotherapy. We report a 12-month-old male child who developed a severe cutaneous reaction that consisted of a widespread pruritic papular eruption associated with fever and a poor general state after dactinomycin administration. Skin biopsy specimen findings confirmed the diagnosis of lichenoid eruption. The rash improved with topical steroid treatment and completely resolved within 1 month with persistence of a residual mild hyperpigmentation. Dactinomycin administration was discontinued for the remaining cycles of chemotherapy.
- Subjects
MEDICAL literature; SKIN diseases; THERAPEUTICS; ITCHING; SKIN; BIOPSY
- Publication
Pediatric Dermatology, 2006, Vol 23, Issue 5, p503
- ISSN
0736-8046
- Publication type
Article
- DOI
10.1111/j.1525-1470.2006.00294.x